Posted to MedZilla on 5/23/2019

Takeda Pharmaceuticals

US-MA, Associate Medical Director, Translational Medicine R0007670-MZ


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Job Description

Are you looking for a patient-focused company that will inspire you and support your career? If so, be empowered to take charge of your future at Takeda. Join us as an Associate Medical Director in our Cambridge office.

Here, everyone matters and you will be a vital contributor to our inspiring, bold mission. As a Associate Medical Director working on the Translational Science team, you will be empowered to serve as a key molecular diagnostics leader within the new Translational Sciences group and provide pathology expertise to assist groups that are developing human tissue-based model systems, and a typical day will include:

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  • Serve as a key molecular diagnostics leader within the new Translational Sciences group, reporting to the Head of Translational Sciences.
  • Integrate into multi-disciplinary project teams to create translational strategies that can bridge between discovery and development efforts, within and across immune-oncology programs.
  • Provide cross-functional expertise in translating research findings from in vitro/vivo model systems to clinically-relevant biomarker signatures and patient stratification strategies
  • Apply molecular pathology expertise to leverage the integration of multi-omics analyses with spatial image profiling to support and expand R&D programs.
  • This is a highly collaborative role involving cross-functional collaborations across immune-onclogy programs and the clinical development teams at Takeda Oncology in Cambridge, MA. The overall goal will be to assimilate discovery findings to rationally inform the development of clinical biomarker and patient stratification strategies.


Cross-Program Collaborations To Drive Translation:

  • Embed in early discovery projects to provide cancer biology/pathology expertise that will help inform development directions, including mechanisms of action and pharmacodynamics.
  • Foster translation by providing expertise to identify predictive biomarkers and inform directions of clinical diagnostic assays.
  • Identify appropriate testing platforms, CROs, and/or academic groups that are essential for discovery and/or clinical research support, with oversight when needed.
  • Leverage expertise in clinical pathology to contribute to identification of relevant tumor indications to help maximize patient benefit.
  • Prepare technical reports, protocols, and applications where necessary.

Technologies and Innovation:

  • Provide pathology expertise to assist groups that are developing human tissue-based model systems.
  • Provide pathology review of tissue slides used in multiplexed-immunofluorescence profiling and help inform spatial analysis parameters that will best address project questions.
  • Work within an integrative team across the computational biology, multi-omics, and spatial profiling groups to help drive discovery efforts.
  • Collaborate with molecular genomics team leveraging knowledge of the application of omic technologies in the clinical setting to benefit development of preclinical studies developing and testing forward and reverse translation hypotheses.

Human Biobank Support:

  • Work closely with the biobanking group to identify specific human tumor samples that are required to successfully inform translational strategies.
  • Participate in quality metric assessments of samples entering the biobank, including H&E slide review and diagnosis confirmation.
  • Demonstrates broad technical program knowledge
  • Acts as the recognized pathology expert on an aspect of a program
  • Demonstrates effective project management skills
  • Develops and oversees application of pathology insights into the translational strategy of project teams and will manage the work of others directly or in a matrixed structure
  • Independently manages workload and expectations
  • Scientifically independent
  • Provides information to group to influence direction, departmental goals and/or business
  • Collaborates with others, and acts as scientific resource for an aspect of a program
  • Participates in external interactions and collaborations
  • Receives high level instructions on work; determines methods on new assignments; clear scientific independence
  • May have direct reports


  • MD, or internationally recognized equivalent degree, list of publications, grants, research awards etc)
  • Board certification or board eligible in Anatomic Pathology and/or Clinical Pathology
  • Experience with molecular genomics preferred
  • Excellent oral and written communication skills, including writing, reviewing and editing scientific documents
  • Superior interpersonal skills, diplomacy and positive influencing abilities
  • Ability to work and drive decision-making within a multi-disciplinary, multi-regional, matrix teams
  • Good fit with Takeda core values and leadership principles
  • Right attitude (agile, curious, open-minded, can-do mindset)
  • Superior therapeutic area knowledge and solid understanding of emerging research in designated therapeutic area (if applicable)


  • Ability to drive to or fly to various meetings or R&D sites including overnight trips
  • Ability to spend longer period of time at a different R&D site (weeks or several months)
  • Some international travel may be required.


401(k) with company match and Annual Retirement Contribution Plan

Tuition reimbursement

Company match of charitable contributions

Health & Wellness programs including onsite flu shots and health screenings

Generous time off for vacation and the option to purchase additional vacation days

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Boston, MA

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Full time

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