Posted to MedZilla on 5/23/2019

Takeda Pharmaceuticals

US-MA, Scientist 1, Immuno-Oncology R0007532-MZ


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Job Description

Are you looking for a patient-focused company that will inspire you and support your career? If so, be empowered to take charge of your future at Takeda. Join us as a Research Scientist I in our Cambridge office.

Here, everyone matters and you will be a vital contributor to our inspiring, bold mission. As a Research Scientist I working on the Immuno-Oncology team, you will be empowered to contribute to preclinical projects by designing, executing, and analyzing in vitro and in vivo experiments and contribute to novel and differentiated therapeutic approaches, and a typical day will include:

Takeda s Immuno-Oncology team is seeking a highly-motivated immunologist to contribute to preclinical projects by designing, executing, and analyzing in vitro and in vivo experiments. Our new team member will have the opportunity to contribute to novel and differentiated therapeutic approaches by both advancing internal projects as well as working with external partners. The successful candidate will be at the forefront of Immuno-oncology, a field that is bringing

revolutionary treatments to oncology patients.


  • Mastery of basic immunology and knowledgeable of current advances
  • Contribute both intellectually and experimentally to preclinical projects from inception through clinical development
  • Mentor colleagues less familiar with immunology
  • Impact highly-matrixed and diverse teams using clear communication and collaborative spirit
  • Work independently to propose, design, execute, troubleshoot, analyze, and present in vitro and in vivo experiments
  • Evaluate test molecules in syngeneic murine tumor models
  • Establish in vitro assays for the evaluation of T cells, dendritic cells, macrophages, and other immune cells
  • Execute in vitro experiments investigating immune cell differentiation, characterization, cytokine production, proliferation, and cytolytic activity
  • Isolate and culture primary immune cells from human PBMCs and murine spleen, lymph node, and tumor
  • Design and perform multi-parameter flow cytometry experiments to phenotype primary human and murine immune cells
  • Analyze and interpret complex data sets (RNA expression, proteomics, cytokine analysis, multi-parameter flow cytometry)
  • Propose novel projects based on internal results, external partners, and published reports


  • Ph.D. in Immunology with 0-3 years of post-graduate experience
  • Publications in peer-reviewed journals demonstrating expertise and achievements in the Immunology field
  • Experience working with primary human cells and tissues
  • Experience working with syngeneic mouse models in the context of immune or cancer biology, including hands-on experience with ex vivo isolation and manipulation of various immune cell subsets from mouse tissues
  • Experience carrying out T cell functional assays, including evaluating responses to specific antigens
  • Experience culturing and manipulating primary innate immunocytes (macrophages, dendritic cells)
  • Hands-on experience and ability to work with minimal supervision in carrying out FACS analysis with cytometers such as LSRII, FACS CANTO, and FACS ARIA II/III
  • Proficiency in molecular/immunological assays such as ELISA/Luminex, qRT-PCR and TR-FRET
  • Good communications skills, both oral and written
  • Excellent analytical, organizational, interpersonal and time management skills
  • Strong team player who thrives in a dynamic, biotech-like environment


  • Requires less than 10% travel, including international


401(k) with company match and Annual Retirement Contribution Plan

Tuition reimbursement

Company match of charitable contributions

Health & Wellness programs including onsite flu shots and health screenings

Generous time off for vacation and the option to purchase additional vacation days

Community Outreach Programs

Empowering Our People to Shine

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Boston, MA

Worker Type


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Time Type

Full time

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