The intern in the Drug Metabolism and Pharmacokinetic (DMPK) Translational Research group at TCAL will quantify protein biomarkers of pathway modulation using high-resolution mass spectrometry
- Perform basic laboratory functions including sample handling, buffer preparation, enzymatic reactions, liquid-liquid extraction, solid phase extraction, derivatization and gel separation
- Develop chromatography and mass spectrometry methods for targeted proteins identified in discovery datasets.
- Execute differential and statistical analysis of mass spectrometry data to identify and quantify biomarkers of disease, pathway modulation, and efficacy.
- Perform pathway analysis to map changes in metabolic/ biological pathways and lead to mechanistic understanding of the disease and drug efficacy
- Keep an accurate, comprehensible, concise notebook in accordance with company policy
EDUCATION, EXPERIENCE, KNOWLEDGE AND SKILLS:
- Undergraduate student in good academic standing with a major in Analytical Chemistry, Protein Chemistry, Biochemistry, Biology, Pharmacology, or related fields (Second or third year students preferred)
- Ideal candidate should have an excellent academic record and hands-on laboratory work experience
- Highly motivated with a strong interest in translational research and quantitative analysis
- Students must be legally authorized to work in the United States.
- Expected hours: 10 - 20 hours while school is in session; up to 40 hours during school breaks
- Candidates with knowledge/ experience in mass spectrometry and chromatography are preferred.
San Diego, CA
Paid Intern (Fixed Term) (Trainee)