Posted to MedZilla on 2/22/2019

Takeda Pharmaceuticals

US-CA, Intern, Drug Metabolism and Pharmacokinetics R0006379-MZ


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Job Description


The intern in the Drug Metabolism and Pharmacokinetic (DMPK) Translational Research group at TCAL will quantify protein biomarkers of pathway modulation using high-resolution mass spectrometry


  • Perform basic laboratory functions including sample handling, buffer preparation, enzymatic reactions, liquid-liquid extraction, solid phase extraction, derivatization and gel separation
  • Develop chromatography and mass spectrometry methods for targeted proteins identified in discovery datasets.
  • Execute differential and statistical analysis of mass spectrometry data to identify and quantify biomarkers of disease, pathway modulation, and efficacy.
  • Perform pathway analysis to map changes in metabolic/ biological pathways and lead to mechanistic understanding of the disease and drug efficacy
  • Keep an accurate, comprehensible, concise notebook in accordance with company policy


  • Undergraduate student in good academic standing with a major in Analytical Chemistry, Protein Chemistry, Biochemistry, Biology, Pharmacology, or related fields (Second or third year students preferred)
  • Ideal candidate should have an excellent academic record and hands-on laboratory work experience
  • Highly motivated with a strong interest in translational research and quantitative analysis
  • Students must be legally authorized to work in the United States.
  • Expected hours: 10 - 20 hours while school is in session; up to 40 hours during school breaks
  • Candidates with knowledge/ experience in mass spectrometry and chromatography are preferred.


San Diego, CA

Worker Type


Worker Sub-Type

Paid Intern (Fixed Term) (Trainee)

Time Type

Part time

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