|Are you looking for a patient-focused company that will inspire you and support your career? If so, be empowered to take charge of your future at Takeda. Join us as a Senior Scientist, Biomedical Informatics in our San Diego office.|
Here, everyone matters and you will be a vital contributor to our inspiring, bold mission. As a Senior Scientist working on the R&D Biomedical team, you will be empowered to lead bioinformatics and computational biology strategy of target selection, validation, and mechanism of action investigations across multiple therapeutic areas such as gastrointestinal diseases and CNS.
Senior Scientist will be part of a team focused on computational biology support
of reverse translation across multiple therapeutic areas of interest of Takeda.
The Senior Scientist will apply expertise in bioinformatics and
computational biology to analyze various types of molecular profiling and
phenotype data for the identification and characterization of genes, networks
and pathways involved in normal and perturbed physiology. This information will
be used to understand the molecular basis of disease pathology and the
mechanism of action of drugs, and ultimately be used for selection and
progression of drug targets.
computational analysis of RNA-seq, other OMICS and real-world data from
internal, collaboration and public sources. Applies unsupervised and supervised
machine learning and other advanced algorithms to extract novel biologically
statistical genetics analyses to internal and external genetics data to support
or falsify target hypotheses.
genomics, genetics, epigenetics and literature data to strengthen understanding
of diseases and treatment perturbations.
multiple approaches for analyses of genes, pathways and networks.
biological databases and provides relevant biological context to large lists of
differentially expressed or regulated genes and prioritize them.
analysis and interpretation of data, specifically for the selection of new drug
study reports and presents data effectively in all settings and with
participants of all levels of the organization.
EXPERIENCE, KNOWLEDGE AND SKILLS:
- PhD or equivalent with
Post Doc and at least 4 years of bioinformatics experience OR
- MS/MA with 14+ years of
relevant experience OR
- BS/BA with 16+ years of
a solid background in basic cellular and molecular biology with an
understanding of a range of disease areas including neurobiology,
gastroenterology, immunology and oncology. Exposure to a wide variety of
therapeutic areas such as CNS, gastroenterology and oncology is a plus.
in the use of R (Bioconductor), Python, and/or other languages commonly used
for bioinformatics analysis. Must be
expert in applying major bioinformatics tools such as Omicsoft ArrayStudio,
Cytoscape and Clarivate Metacore
be expert in sequencing data analysis such as RNAseq, DNAseq, scRNA-seq, etc.
with microbiome data is a plus
the advantages and limitations of various types of human genetic datasets (e.g.
GWAS, CNVs, Rare variants, etc.) and has hands on experience in using public
human genetics and epigenetics databases.
able to develop creative methods for integration of human genetic and
epigenetic data with our proprietary mouse gene expression data to create a
more robust drug target selection pipeline.
be able to apply methods of unsupervised machine learning algorithms such as
WGCNA, K-means, Hierarchical, DBSCAN, and/or Spectral clustering
be able to apply methods of dimensionality reduction algorithms such as
Non-negative Matrix Factorization (NMF), Principal Component Analysis (PCA),
Independent Component Analysis (ICA), Manifold Learning and similar techniques.
be expert and able to apply advanced machine learning methods such as Hidden
Markov Chain, Support Vector Machines, neural nets and deep learning algorithms.
communication and team working abilities to contribute in a team that operates
as a unit on large projects.
be able to apply network modeling methods
with text mining algorithms is a plus
handling and reaching for objects up to 25 lbs.
to work in a lab environment
to 20% travel, both domestic and internationally may be required.
WHAT TAKEDA CAN OFFER YOU:
401(k) with company match and Annual Retirement Contribution Plan
Company match of charitable contributions
Health & Wellness programs including onsite flu shots and health screenings
Generous time off for vacation and the option to purchase additional vacation days
Community Outreach Programs
Empowering Our People to Shine
Learn more at takedajobs.com.
Takeda is an EEO employer of minorities, women, disabled, protected veterans, and considers qualified applicants with criminal histories in accordance with applicable laws. For more information, visit http://www.takeda.us/careers/EEO_Policy_Statement.aspx
No Phone Calls or Recruiters Please.