The intern in the Drug Metabolism and Pharmacokinetic (DMPK) Translational Research group at TCAL will quantify biomarkers of pathway modulation using high-resolution mass spectrometry
Perform basic laboratory functions including sample handling, buffer preparation, enzymatic reactions, liquid-liquid extraction, solid phase extraction, derivatization and gel separation
Develop chromatography and mass spectrometry methods for targeted proteins identified in discovery datasets.
Execute differential and statistical analysis of mass spectrometry data to identify and quantify biomarkers of disease, pathway modulation, and efficacy.
Perform pathway analysis to map changes in metabolic/ biological pathways and lead to mechanistic understanding of the disease and drug efficacy
Keep an accurate, comprehensible, concise notebook in accordance with company policy
Education, Experience, Knowledge and Skills Undergraduate student in good academic standing with a major in Analytical Chemistry, Protein Chemistry, Biochemistry, Biology, Pharmacology, or related fields (Second or third year students preferred)
Ideal candidate should have an excellent academic record and hands-on laboratory work experience
Highly motivated with a strong interest in translational research and quantitative analysis
Students must be legally authorized to work in the United States.
Expected hours: 10 - 20 hours while school is in session; up to 40 hours during school breaks
Candidates with knowledge/ experience in mass spectrometry and chromatography are preferred.
San Diego, CA
Paid Intern (Fixed Term) (Trainee)