Posted to MedZilla on 11/14/2019

Takeda Pharmaceuticals

US-CA, Scientist I Structural Biology protein crystallography and cryoEM R0012926-MZ


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Job Description

Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a Scientist I Structural Biology protein crystallography and cryoEM at our recently dedicated San Diego Research Site.

At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

Here, you will be a vital contributor to our inspiring, bold mission. As a Scientist I Structural Biology protein crystallography and cryoEM, you will be empowered to serve on project teams for discovery to development programs.


  • Seeking a highly motivated and collaborative Scientist I, Structural Biology, to provide expertise in 1) recombinant protein expression/purification, and 2) crystallographic/cryoEM structure determination of soluble and membrane proteins, protein-protein complexes and protein-ligand complexes to support Takeda s drug discovery programs.
  • This individual works collaboratively and effectively with other biologists, protein chemists, crystallographers and biophysicists in determining methodologies and strategies that best support Takeda s internal and external drug discovery programs.
  • Contributes to design, development and execution of research assignments, potentially contributing to multiple projects


  • Responsible for high-resolution cryoEM and crystallographic structure determination of proteins complexed with both large and small molecules and for supporting Structure-Based Drug Design (SBDD) and Fragment- Based Lead Discovery (FBLD)
  • Strong aptitude for using structural data to help interpret data from other disciplines to generate testable SAR hypotheses and drive progress on portfolio programs
  • Work collaboratively on pipeline projects with an interdisciplinary group of both internal and external project team members including disease-area biologists, medicinal chemistry, computational chemistry, in vitro/in vivo pharmacology, informatics, DMPK, DSRE, and project management
  • Responsible for optimizing expression and purification of proteins, including integral membrane proteins, from a variety of expression hosts
  • Perform high-throughput crystal screening and optimization as well as cryoEM grid preparation across a number of platforms utilizing multiple methods, including automation.
  • Utilize structural biology software packages including Coot, Phenix, Relion and CCP4 to provide high quality structural data for project teams.
  • Communicate structural data to various audiences, as well as interpretation and significance of the data, to help to drive the molecule design/testing iterations
  • Maintain up-to-date understanding of the state of the field in cryoEM, x-ray crystallography structural biology as a whole and more broadly across drug discovery
  • Initiate investigation of new experimental approaches to a wide range of problems using
    scientific theory and technical literature


Technical/Functional (Line) Expertise

  • Demonstrated ability to rigorously and efficiently solve high quality structures of biological complexes of interest using cryoEM and x-ray crystallography
  • Experienced in all aspects of cryoEM and crystallographic workflows and in solving difficult structural biology challenges
  • Deep experience in membrane protein expression and purification
  • Expertise in structure determination software including Relion, CCP4, Phenix, and Coot. Experience with MOE and PyMol is highly desirable
  • Deep understanding of protein structure and function, with the ability to clearly communicate structural information and significance/interpretation to a broad audience
  • Rigorous, exacting, organized, creative and innovative approach to scientific inquiry.
  • Experience in various aspects of computational chemistry, including molecular docking and virtual screening, is a plus
  • Enthusiasm for structural biology, drug discovery, and collaboration in an industrial setting


  • Identifies, plans and executes novel scientific projects and may manage the work of others a direct or matrixed structure

Decision-making and Autonomy

  • Independently manages workload and expectations
  • Scientifically independent
  • May influence decision making within the department


  • Conducts scientific presentations to internal audiences


  • Receives high level instructions on all work, determines methods on new assignments, works closely with manager, may manage junior staff


  • PhD degree in a scientific discipline

  • 401(k) with company match and Annual Retirement Contribution Plan
  • Tuition reimbursement
  • Company match of charitable contributions
  • Health & Wellness programs including onsite flu shots and health screenings
  • Generous time off for vacation and the option to purchase additional vacation days
  • Community Outreach Programs

Empowering Our People to Shine

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San Diego, CA

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Full time

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