US-MA, Quantitative Safety Pharmacology Modeler R0011047-MZ
Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a Quantitative Safety Pharmacology Modeler in our Quantitative Solutions team in our Cambridge, MA office.
At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.
Here, you will be a vital contributor to our inspiring, bold mission.
The quantitative translational science department of Takeda Pharmaceuticals in Cambridge MA is seeking a quantitative safety pharmacology modeler to support global drug development by building system safety pharmacology/toxicology models such as cardiac ion channel inhibition, myelosuppression, gastrointestinal toxicity, cytokine release syndrome and drug induced liver injury models. The successful candidate will collaborate with nonclinical drug safety, drug discovery, drug metabolism, and clinical pharmacology to develop mathematical models to understand the targeted biological pathways and exposure-safety relationship of novel therapeutic agents. The candidate will also be responsible for implementing the right modeling & simulation strategy to assist with lead optimization, establish TK/TD relationships and create mechanistic safety pharmacology models to support project needs. Essential qualifications include in depth understanding of safety pharmacology, particularly in immunology and cardiovascular biology, and numerical methods, as well as hands-on experience with modeling software, and ability to clearly present modeling and simulation findings.
EDUCATION, EXPERIENCE, KNOWLEDGE AND SKILLS:
WHAT TAKEDA CAN OFFER YOU:
Empowering Our People to Shine
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