Posted to MedZilla on 11/12/2019

Takeda Pharmaceuticals

US-MA, Principal Scientist - Analytics R0010992-MZ


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Job Description

Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a Principal Scientist - Analytics in our Cambridge office.

At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Futureto people around the world.

Here, you will be a vital contributor to our inspiring, bold mission.

As a Principal Scientist - Analytics, you will be empowered to build high throughput, state of art Protein Analytics technology platforms and lead developability assessment studies. A typical day will include:


  • Organizational and strategic leadership to build a Global Biologics Protein Analytics sub team with highly efficient biologics characterization workflow using wide range of state of art analytical and biophysical methods


  • Build high throughput, state of art Protein Analytics technology platforms to support analytical characterization of lead candidates with diverse and novel modalities including bispecifics, protein fusions, drug conjugates, cell therapies, and gene therapies
  • Devise and implement both protein analytics and biologics discovery strategies as co-lead for discovery stage programs spanning multiple therapeutic areas including I/O-Oncology, GI/Immunology, CNS and Rare Disease
  • Lead developability assessment studies and coordinate Research to Development transition (R2D) of candidates
  • Play crucial role in devising analytical strategy of the programs and implement stage appropriate analytical methods for progress of programs in discovery through early development
  • Effective collaboration with multiple teams from discovery and development organization to accelerate programs to IND
  • Functional area leader with strong expertise in biologics characterization
  • Desirable: deep expertise in wide range of biophysical and analytical methods including
    • UPLC/HPLC based methods, cg., SEC, RP, HIC, IEX
    • Mass spec based methods to characterize intact mass, peptide mapping, Glycan profile, oxidation-deamidation hot spot detection, etc.
    • Light scattering: DLS and MALS
    • Thermal stability and protein folding
    • Stress studies
    • Formulation screen
  • Program leadership: Engage in both biologics lead and protein analytics lead roles to drive strategy of global biologics programs
  • People leadership: Manage and mentor a team of scientists in fast paced matrix environment and groom them to be future leaders
  • Independently manages workload and expectations
  • Scientifically independent
  • Scientific driver for research strategy that impacts group internally and outside area of function


  • PhD degree in a scientific discipline with 8+ years experience , or
  • MS with 12+ years experience, or
  • BS with 14+ years experience
  • Minimum 5 years of industry experience in hands on analytical characterization of biologics is required
  • Project and people management experience is desired
  • Functional area leader with strong expertise in Biologics Characterization using wide range of state of art analytical and biophysical methods
  • Effective project and resource management skills in matrix organization
  • Building new capabilities to broaden scope and capacity of Protein analytics workflow
  • Excellent oral and written communication skills to present data and strategy across Takeda network involving multiple sites and disease areas


  • 401(k) with company match and Annual Retirement Contribution Plan
  • Tuition reimbursement Company match of charitable contributions
  • Health & Wellness programs including onsite flu shots and health screenings
  • Generous time off for vacation and the option to purchase additional vacation days
  • Community Outreach Programs

    Empowering Our People to Shine

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    No Phone Calls or Recruiters Please.



Boston, MA

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Full time

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