Posted to MedZilla on 12/9/2019

Takeda Pharmaceuticals

US-MA, Translational Research Lead, Rare Disease R0008459-MZ


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Job Description

Are you looking for a patient-focused company that will inspire you and support your career? If so, be empowered to take charge of your future at Takeda. Join us as a Translational Research Lead, Rare Disease

in our Cambridge office.

Here, everyone matters and you will be a vital contributor to our inspiring, bold mission.


This position is part of a Rare Disease Therapeutic Area Unit (TAU); Search and Translational Science Group, which will be responsible for transition of programs between preclinical into early clinical research. The Translational Research Lead will work very closely with the Translational Medicine Physician and collaborate with the Drug Discovery Unit and Global Project Teams in the Rare Disease Therapy Area (TA).

The position is accountable for primarily defining the preclinical translational plan, identification of targets, disease pathways and biomarkers for efficacy and safety, identification and generation of nonclinical models with mechanistic alignment to human disease mechanisms. This will require interaction with various functions and subject matter experts to achieve a plan that can be exected with agility.

The individual will be expected to develop networks with academic, biomedical research organizations and clinical groups working in discovery biology and/or translational sciences space to deliver data to support a differentiated asset aligned to the Rare Disease TA strategy.

The working model is truly adaptable and operates by a lean and entrepreneurial team utilising external services and tapping into the extensive knowledge based network (internal and external). The position will also build a network within Takeda Rare Drug Discvovery Unit (DDU) to identify new opportunities of areas of mutual interest and to seek internal experts for validation of ideas and experimental plans where appropriate.

The position will provide a challenge the staus quo perspective when collaborating and problem solving to deliver therapeutic candidates in a more resource and cost efficient manner.


  • Design and coordinate translational studies to define differentiated assets; interpret data in consultation with external vendors, academics, etc, & make recommendations.
  • Generate in in collaboration with relevant colleagues and experts a road map to achieve a rapid preclinical proof of concept for agreed indication(s), providing scientific input to translational sciences plans to ensure pivotal activities are incorporated within the scope of resource and budget.
  • Support search activities to identify new programs and technologies suitable for rare diseases, including involvement in due diligence activities and partnering recommendations.
  • Liaise with Corporate IP team to ensure patent strategies are defined and new data reported in support of IP generation.
  • Establish a network of experts in a variety of disease areas to advise on research plans and maintain collaborative relationships.
  • Supplement in-house expertise with external resources to validate assets in new therapeutic areas.
  • Communicate scientific materials to external investors working with BD.


  • Advanced scientific degree (PhD) required.
  • 8+ years experience in the pharmaceutical or biomedical industry in a research environment with evidence of developing translational plans.
  • Ability to motivate, negotiate and problem solving. This role will require coordination with external vendors and consultants as necessary.
  • Have scientific understanding & experience of early development and translational sciences. Experience of rare disease development would be advantageous.
  • Experience of working at the interface with research and development.
  • An established track record of effective and influential oral presentations.
  • Experience of supporting search activities providing scientific input to identify opportunities and input into due diligence activities Search activities and diligence
  • Strong interpersonal and people skills, the successful candidate will have a proven background interacting with individuals at a variety of functional levels with both internal and external personnel.
  • Highly collaborative to work cross functionally, who is motivated to drive projects forward and willing to execute the plan to completion. A can-do attitude is essential.
  • Operates with a sense of urgency and proactively responds to problems and opportunities using a resourceful and innovative mindset with enthusiasm in a timely matter.
  • Results and performance driven, assuming personal ownership and accountability for business results and solutions.
  • Can operate with minimum supervision.
  • Fluent in English.


The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions:

  • Manual dexterity required to operate office equipment (i.e. computers, phones, etc.)
  • Ability to sit for long periods of time
  • Carrying, handling, and reaching for objects
  • Ability to drive to or fly to various meetings/client sites/HQ.
  • International travel (20-30%), including some weekend commitments.
  • Ability to use field based telephonic and computer tools for all aspects of the job is critical.


  • 401(k) with company match and Annual Retirement Contribution Plan
  • Tuition reimbursement
  • Company match of charitable contributions
  • Health & Wellness programs including onsite flu shots and health screenings
  • Generous time off for vacation and the option to purchase additional vacation days
  • Community Outreach Programs

Empowering Our People to Shine

Takeda is an EEO employer of minorities, women, disabled, protected veterans, and considers qualified applicants with criminal histories in accordance with applicable laws. For more information, visit

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Cambridge, MA

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Full time

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