Posted to MedZilla on 7/15/2018

Takeda Pharmaceuticals

US-CA, Principal Scientist - GI Chemistry San Diego, CA R0002695-MZ


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Job Description

Are you looking for a patient-focused company that will inspire you and support your career? If so, be empowered to take charge of your future at Takeda. Join us as Principal Scientist in our Gastrointestinal Chemistry team at our San Diego site.

Here, everyone matters and you will be a vital contributor to our inspiring, bold mission. As a Principal Scientist, GI Chemistry, you will be empowered to define project goals and strategy through collaboration with a cross-functional team.


  • The Principal Scientist GI Chemistry will be based in our Takeda California location and report to a Director or Senior Director, GI Chemistry. The Principal Scientist, GI Chemistry leads inspires and motivates chemistry and interdisciplinary project teams.
  • Demonstrates a deep understanding of medicinal chemistry principles and their application within an integrated drug discovery environment. Responsible for setting strategies, priorities and managing activities to deliver on objectives and milestones.
  • Capable of multitasking, including leading one or more discovery programs from hit to tool/lead and/or lead optimization.
  • Collaborates with cross-functional partners to define and implement strategies for drug discovery programs from target validation to hit-to-tool/lead and/or lead optimization to candidate nomination and selection using internal, external (CRO) and partner resources.
  • Provides highly competent medicinal chemistry input in evaluation of external/partnership opportunities, including participating in diligence exercises.
  • Provides mentorship and proactively supports the professional development of line reports and colleagues


  • Ability to formulate project level goals and strategy though collaboration with other members of the organization.
  • Partners with cross-functional teams to generate data in support of project goals & deliverables to drive key Go/No Go decisions for drug discovery programs.
  • Leads chemistry and/or cross-functional teams (in-house and with partners) in defining, aligning, and implementing strategies for hit identification, hit-to-tool optimization, lead optimization and delivery of candidate molecules.
  • Independently leads, inspires and motivates both chemistry teams and multidisciplinary project teams. Capable of multitasking, including leading one or more hit to tool/lead and/or lead optimization programs while maintaining lab presence.
  • Conceives and applies an integrated chemistry strategy and appropriately prioritizes resources to optimally meet project goals.
  • Establishes customized in vitro and in vivo compound testing flow schemes to support programs at all stages.
  • Effectively manages internal and CRO chemists. Able to rapidly shift resources and reprioritize in response to data.
  • Demonstrates inter-disciplinary knowledge of drug discovery (in vitro/in vivo pharmacology, ADME, PK/PD/E, translational research & toxicology) in order to assess druggability and able to use this knowledge to influence project strategy.
  • Committed to maintaining up-to-date knowledge of med chem. and GI-targeted drug delivery and related areas through scientific literature review and trainings.
  • Prepares and organizes data for presentation. Presents written and oral reports to management. Communicates research efforts to collaborators, corporate partners, or at scientific meetings.
  • Publishes original research and review articles in scholarly journals to enhance the chemistry team and Takeda s reputation.
  • Adaptable and dependable manager of both junior and senior scientists, demonstrating exemplary behaviors and able to support and enhance career development of all line reports
  • Embraces and fosters Takeda culture and displays exemplary behaviors consistent with Takeda s core values and mission.


  • Ph.D. in Organic/Medicinal Chemistry with thesis, publication(s), postdoctoral experience, and a minimum of 8 years relevant scientific and technical experience including industry experience or MS with 18 years relevant scientific and technical experience is required.
  • Knowledgeable in all aspects of drug discovery from target discovery through to early clinical development is preferred.
  • Demonstrated competency in hypothesis-based medicinal chemistry. Track record of project leadership in driving discovery programs to key pre-clinical G/NG decision points, including the successful identification of development candidates.
  • Demonstrated ability to work in a dynamic multidisciplinary community and matrix organization.
  • Experience in late stage optimization and preclinical evaluation of small molecule drugs, including a detailed knowledge of the roles of DMPK, drug safety, CMC, formulation and translational research. Able to define and influence pre-clinical and early clinical development strategy.
  • Positive can-do attitude with excellent written/verbal communication and collaboration skills and ability to work with cross-functional scientists. Ability to clearly and concisely convey ideas and opinions
  • Highly motivated and flexible with ability to work in fast-paced environment. Ability to provide novel, creative solutions to challenging problems. Desire to learn and tackle new challenges and initiatives.
  • Professionally represents the organization in collaborations, partnership discussions, and external relationships and conferences
  • Experience in effectively managing more junior personnel and able to identify and create personalized development opportunities for line reports.


  • Manual dexterity required to operate office equipment (i.e., computers, phones, etc.).
  • Carrying, handling and reaching for objects.
  • Ability to stand and work in a laboratory environment


  • Willingness to travel to various meetings or client sites, including overnight trips. Some international travel may be required.
  • Requires approximately 5% travel.


  • 401(k) with company match and Annual Retirement Contribution Plan
  • Tuition reimbursement
  • Company match of charitable contributions
  • Health & Wellness programs including onsite flu shots and health screenings
  • Generous time off for vacation and the option to purchase additional vacation days
  • Community Outreach Programs

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