Posted to MedZilla on 6/23/2018

Takeda Pharmaceuticals

US-MA, Research Investigator - Histotechnologist R0002402-MZ


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Job Description

We are looking for an experienced individual with a strong background in histology who is highly motivated and passionate for driving scientific growth in the laboratory by developing additional assays in collaboration with a dynamic team of investigative toxicologists and pathologists as part of nonclinical safety assessment of new drug candidates.

The ideal candidate will have extensive experience with histology and development of new protocols in immunohistochemistry, in situ hybridization, ability to independently troubleshoot and solve technical problems, work in a highly collaborative environment, and excellent interpersonal skills.

Job Description

  • Primary responsibility includes performing routine histologic processing of formalin-fixed tissues from rodent toxicity studies.

  • Work on development, optimization, and validation of new assays in immunohistochemistry and in-situ hybridization.

  • Desirable attributes include experience performing frozen samples and execution of existing biomarker assays (mesoscale and Luminex platforms), tissue microarrays and image analysis.

Duties and Responsibilities:

  • Perform basic histology procedures (trimming, processing, embedding, microtomy, staining, and coverslipping)

  • Perform routine H&E staining and special histochemical staining.

  • Perform routine scanning of stained slides with the Aperio ScanScope, manage slide database.

  • Development, optimization, and validation of new assays in immunohistochemistry and in-situ hybridization.

  • Opportunity to develop a strategy for generating traditional biomarkers based on the mesoscale platform and additional tissue-image based technologies including generation of tissue microarrays and image analysis.

  • Maintain proper documentation, archiving and routine quality control on all generated specimens and data.

  • Maintain adequate stock and efficient use of supplies necessary for performing all procedures, and preparation of reagents as required.

  • Maintain laboratory equipment and assists with identification and execution of process improvement.

  • Ensure and maintain molecular safe integrity and quality of the specimens.


  • Minimum BS or MS degree in a Biological Science or life science.

  • 4+ years of relevant clinical or research laboratory experience.

  • Strong background in IHC/ISH techniques.

  • ASCP certification (or equivalent) is desirable.

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