Posted to MedZilla on 4/20/2018


Takeda Pharmaceuticals

US-MA, Scientist 1, Immuno-Oncology R0001090-MZ


 
 

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Job Description

Takeda s Immuno-Oncology team is seeking a highly-motivated immunologist to contribute to preclinical projects by designing, executing, and analyzing in vitro and in vivo experiments. Our new team member will have the opportunity to contribute to novel and differentiated therapeutic approaches by both advancing

internal projects as well as working with external partners. The successful
candidate will be at the forefront of Immuno-oncology, a field that is bringing

revolutionary treatments to oncology patients.

ACCOUNTABILITIES:

  • Mastery of basic immunology and knowledgeable of current advances
  • Contribute both intellectually and experimentally to preclinical projects from inception through clinical development
  • Mentor colleagues less familiar with immunology
  • Impact highly-matrixed and diverse teams using clear communication and collaborative spirit
  • Work independently to propose, design, execute, troubleshoot, analyze, and present in vitro and in vivo experiments
  • Evaluate test molecules in syngeneic murine tumor models
  • Establish in vitro assays for the evaluation of T cells, dendritic cells, macrophages, and other immune cells
  • Execute in vitro experiments investigating immune cell differentiation, characterization, cytokine production, proliferation, and cytolytic activity
  • Isolate and culture primary immune cells from human PBMCs and murine spleen, lymph node, and tumor
  • Design and perform multi-parameter flow cytometry experiments to phenotype primary human and murine immune cells
  • Analyze and interpret complex data sets (RNA expression, proteomics, cytokine analysis, multi-parameter flow cytometry)
  • Propose novel projects based on internal results, external partners, and published reports

EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS:

  • Ph.D. in Immunology with 0-3 years of post-graduate experience
  • Publications in peer-reviewed journals demonstrating expertise and achievements in the Immunology field
  • Experience working with primary human cells and tissues
  • Experience working with syngeneic mouse models in the context of immune or cancer biology, including hands-on experience with ex vivo isolation and manipulation of various immune cell subsets from mouse tissues
  • Experience carrying out T cell functional assays, including evaluating responses to specific antigens
  • Experience culturing and manipulating primary innate immunocytes (macrophages, dendritic cells)
  • Hands-on experience and ability to work with minimal supervision in carrying out FACS analysis with cytometers such as LSRII, FACS CANTO, and FACS ARIA II/III
  • Proficiency in molecular/immunological assays such as ELISA/Luminex, qRT-PCR and TR-FRET
  • Good communications skills, both oral and written
  • Excellent analytical, organizational, interpersonal and time management skills
  • Strong team player who thrives in a dynamic, biotech-like environment

TRAVEL REQUIREMENTS:

  • Requires less than 10% travel, including international

Locations

Boston, MA

Worker Type

Employee

Worker Sub-Type

Regular

Time Type

Full time


Please visit our website at takedajobs.com

 
 


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