Posted to MedZilla on 6/24/2018

Takeda Pharmaceuticals

US-MA, Associate Scientific Fellow, Fermentation Development R0000321-MZ


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Job Description

Are you looking for a patient-focused company that will inspire you and support your career? If so, be empowered to take charge of your future at Takeda. Join us as an Associate Scientific Fellow - Fermentation Development in our Cambridge office.
Here, everyone matters and you will be a vital contributor to our inspiring, bold mission. As an Associate Scientific Fellow - Fermentation Development working on the Biologics and New Modalities Development team, you will be empowered to develop manufacturing platforms & processes for novel proteins that will be transformative to patients and work with cross-functional teams to move these therapies into the clinic and beyond, and a typical day will include:

  • Lead the establishment of non-mammalian expression and fermentation capabilities for the production of novel (non-mAb/non-Fc) proteins of therapeutic interest. Specific objectives in this area include 1) evaluating and implementing bacterial or other non-mammalian based expression platforms and 2) optimizing fermentation conditions as a means of improving expression levels or reducing COGs to commercially-viable levels.
  • Lead the establishment of internal lab capabilities to support these areas, including identifying and implementing critical technology platforms and equipment
  • Serve as a technical liason with external collaborators in the field, providing expression or fermentation development expertise or support as needed around their assets or technology platforms
  • Assist in the management of Contact Development and Manufacturing Organizations used to advance protein therapeutics into the clinic
  • Represent Pharmaceutical Sciences and work effectively with cross-functional teams including Discovery, Clinical, Toxicology, etc. in developing integrated strategies to accelerate the clinical development and commercialization of protein candidates


Education and Experience:

  • Bachelors degree in chemistry, biology, pharmacy, engineering or related pharmaceutical science and 15+ years relevant industry experience
  • Masters degree in chemistry, biology, pharmacy, engineering or related pharmaceutical science; 13+ years relevant industry experience
  • PhD in chemistry, biology, pharmacy, engineering or related pharmaceutical science; 7+ years relevant industry experience
  • Extensive experience in the expression of non-Fc proteins, including enzymes or other novel scaffolds via bacterial, yeast or other non-mammalian platforms
  • Broad knowledge of fermentation optimization strategies, including the optimization of media and physicochemical parameters and DOE
  • Hands-on familiarity with basic molecular biology techniques for recombinant protein expression and the operation of benchtop stirred-tank bioreactors (of varying scales)
  • Extensive experience in CMC pharmaceutical development for active pharmaceutical ingredients and drug products under cGMP s
  • Significant technical and strategic leadership and accomplishments
  • Experience in working in a multi-disciplinary environment with accountability for informing departmental or functional strategy.
  • Experience leading functional regulatory strategy


  • May require approximately 15-20% travel


  • 401(k) with company match and Annual Retirement Contribution Plan
  • Tuition reimbursement
  • Company match of charitable contributions
  • Health & Wellness programs including onsite flu shots and health screenings
  • Generous time off for vacation and the option to purchase additional vacation days
  • Community Outreach Programs

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