US-MA, Quantitative System Toxicology Modeling & Simulation Scientist 1702784-MZ
Are you looking for a patient-focused company that will inspire you and support your career? If so, be empowered to take charge of your future at Takeda. Join us as a Quantitative System Toxicology Modeling & Simulation Scientist in our Cambridge office.
Here, everyone matters and you will be a vital contributor to our inspiring, bold mission. As a Quantitative SystemToxicology Modeling & Simulation Scientist working on the DMPK team, you will be empowered to influence molecule development and design and build translational PK/PK, TK,TD and mechanistic models and a typical day will include:
The preclinical translational modeling and simulation group of Takeda Pharmaceuticals in Cambridge MA is seeking a quantitative systems toxicology modeling & simulation scientist to support global drug development by building system pharmacology/toxicology models such as intracellular cell growth signaling, tumor growth kinetic, cardiac ion channel inhibition, myelosuppression, gastrointestinal toxicity, and drug induced liver injury models. The successful candidate will collaborate with nonclinical Drug Safety, Drug Discovery, Translational Medicine, and Clinical Pharmacology to develop mathematical models to understand the targeted biological pathways and exposure-toxicity relationship of novel therapeutic agents. The candidate will also be responsible for implementing the right modeling & simulation strategy to assist with lead optimization, establish TK/TD relationships and create mechanistic toxicity models to support project needs. Essential qualifications include in depth understanding of toxicology, cancer biology and numerical methods, as well as hands-on experience with modeling and simulation software, and ability to clearly present modeling and simulation findings.
EDUCATION, EXPERIENCE, BEHAVIOURAL COMPETENCIES AND SKILLS:
WHAT TAKEDA CAN OFFER YOU:
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