|Are you looking for a patient-focused company that will inspire you and support your career? If so, be empowered to take charge of your future at Takeda. Join us as a Staff Scientist, Biomedical Informatics in our San Diego office.|
Here, everyone matters and you will be a vital contributor to our inspiring, bold mission. As a Staff Scientist working on the Research and Development Informatics team, you will be empowered to support bioinformatics and computational biology of target selection, validation, and mechanism of action investigations across multiple therapeutic areas such as gastrointestinal diseases and CNS.
Staff Scientist will be part of a team focused on computational biology support
of reverse translation across multiple therapeutic areas of interest of Takeda.
The Staff Scientist will apply expertise in computational biology and bioinformatics
to analyze large sets molecular profiling and phenotypic data for the identification
and characterization of genes, networks and pathways involved in normal and perturbed
physiology. This information will be used to understand the molecular basis of
disease pathology and the mechanism of action of drugs, and ultimately be used
for prioritization and selection of drug targets.
computational analysis of RNA-seq, other OMICS and real-world data data from
internal, collaboration and public sources. Applies unsupervised and supervised
machine learning and other advanced algorithms to extract novel biologically
multiple approaches for analyses of genes, networks and pathways.
biological databases and provides relevant biological context to large lists of
differentially expressed or regulated genes and prioritize them.
analysis and interpretation of data, specifically for the prioritization of new
study reports and presents data effectively in all settings and with
participants of all levels of the organization.
EXPERIENCE, KNOWLEDGE AND SKILLS:
- PhD or equivalent with
Post Doc and at least 0-3 years of bioinformatics experience, OR
- MS/MA with at least 10 years
of bioinformatics experience OR,
- BS/BA with at least 12 years
of bioinformatics experience
a solid background in basic cellular and molecular biology with an
understanding of a range of disease areas including neurobiology, gastroenterology,
immunology and oncology. Exposure to a wide variety of therapeutic areas such
as CNS, gastroenterology and oncology is a plus.
be expert in sequencing data analysis such as RNAseq, DNAseq, scRNA-seq, etc.
familiar in the use of R (Bioconductor), Python, and other languages, and tools
commonly used for bioinformatics analysis such as Omicsoft ArrayStudio,
Cytoscape and Clarivate Metacore.
the advantages and limitations of various types of human genetic datasets (e.g.
GWAS, CNVs, Rare variants, etc.) and has hands on experience in using public
human genetics databases.
able to develop creative methods for integration of human genetic data with our
proprietary mouse gene expression data to create a more robust drug target selection
be able to apply methods of unsupervised machine learning algorithms such as
WGCNA, K-means, Hierarchical, DBSCAN, and/or Spectral clustering and methods of
dimensionality reduction algorithms such as Non-negative Matrix Factorization
(NMF), Principal Component Analysis (PCA), Independent Component Analysis
(ICA), Manifold Learning and similar techniques.
be familiar and able to apply advanced machine learning methods such as Hidden
Markov Chain, Support Vector Machines, neural nets and deep learning
communication and team working abilities to contribute in a team that operates
as a unit on large projects.
be able to apply network modeling methods
with text mining algorithms is a plus
handling and reaching for objects up to 25 lbs.
to work in a lab environment
WHAT TAKEDA CAN OFFER YOU:
401(k) with company match and Annual Retirement Contribution Plan
Company match of charitable contributions
Health & Wellness programs including onsite flu shots and health screenings
Generous time off for vacation and the option to purchase additional vacation days
Community Outreach Programs
Empowering Our People to Shine
Learn more at takedajobs.com.
Takeda is an EEO employer of minorities, women, disabled, protected veterans, and considers qualified applicants with criminal histories in accordance with applicable laws. For more information, visit http://www.takeda.us/careers/EEO_Policy_Statement.aspx
No Phone Calls or Recruiters Please.