Posted to MedZilla on 9/22/2017

Takeda Pharmaceuticals

US-MA, Head of Genomic Medicine 1701054-MZ


Empowering Our People to Shine

Here, everyone matters and you will be a vital contributor to our inspiring, bold mission. At Takeda, you will make an impact on people s lives including your own.

Since the completion of the Human Genome Project, human genetics and genomics (collectively refers to as genomics) have played an increasingly important role in drug target discovery and validation, particularly as the increasing amount of detailed genomic data empowers researchers to decipher the underlying biological causes of disease. Human genetics and genomics are also playing an important role in the identification of targeted patient populations for drugs. Takeda is committed to implement human genetic/genomic activities in its drug discovery and development process.
Genomic Medicine is a multi-disciplinary, science-driven field enabling genetic/genomic validation of drug targets, safety and efficacy profiling. The vision of the department is to incorporate multi-disease system biology approaches and knowledge integration, patient-centric classification and target discovery/selection for drug development, reverse translation of clinical and genomic information and utilization of human and advanced cellular model systems.

The Head of Genomic Medicine (GM) is responsible for providing the mission and vision and establishing a genomic organization within Translational Research and Early Clinical (TREC), which is under Research Division with the Chief Medical and Scientific office (CMSO). This position will set the strategy for genomic research program within Takeda. He/she will have responsibility for educating, communicating and collaborating with internal therapeutic groups and identifying, interfacing and managing external groups with specific know-how, technical platforms and other necessary capabilities to implement genetic activities and knowledge into all phases of Takeda projects. It is particularly important to partner with internal groups including the Drug Discovery Units, Therapeutic Area Units, Translational and Biomarker Research, and the Data Science Institute. The head will also provide direction for the internal and external genomic program execution. An externally facing approach is important, including partnerships with academic and clinical centers, consortia and patient advocacy groups to access patient data and samples for disease-focused research and well-characterized clinical trial participants.
A key objective of this position is to provide deep understanding of human genetics, disease mechanisms, increases the likelihood of success of proposed targets and promotes innovative thinking for effective drug development decisions. Ultimately, this position will facilitate the identification and validation of targets, biomarkers and enable reverse translation of human data in partnership with other functions.
The Head of GM is expected to have significant interaction with other Divisions within Research and other CMSO divisions.


  • Develop genomic strategy within Takeda.
  • Responsible for the use of human genomic results for drug target discovery and validation.
  • Early engagement with Drug Discovery Units (DDUs) to assist in research portfolio prioritization.
  • Provide genetic/genomic expertise to DDUs to assist on go/no-go decisions at stage-ups.
  • Responsible for education and informing Takeda scientists on disease specific genomic strategy.
  • Develop strategy for acquiring large cohorts and big datasets in various diseases are of interest to Takeda in collaborations with divisions such as Data Science Institute.
  • Establishes and direct a cross matrix team to provide overall strategic and technical direction and scientific expertise in the area of genomic.
  • Establishes process to evaluate external opportunities and latest scientific development/innovations. Serve as Takeda liaison with academic institutes in matters of human genomic.
  • Establishes and maintains strong relationships with key consultants, opinion leaders and key investigators in genomic and therapeutic area(s) relevant to Takeda s strategy.
  • Provide expert genetic/genomic knowledge, guidance and strategic input into Clinical Development Plans, and study conduct as needed. Provide interpretation of genetic basis of clinical trial results.
  • Serves as the main point of contact for genomic related scientific issues and interpretation of genetic data.
  • Ensure agile, timely management of issues arising from ongoing studies (e.g. adverse events).
  • Oversees all resource and finance forecasting (including due diligence) and oversees budget management for internal program and external collaborations ensuring alignment of financial forecasts and deliverables
  • Hires, manages and develops staff to support achievement of strategic goals.
  • Responsible for performance management of staff, define performance metrics, assessment of training needs, coaching and mentoring in support of performance management. Oversees and manages functional and administrative budget.
  • Oversight of vendors and budget/ contract negotiation as needed.
  • Contributes to authorship, review and approval of key documents, including investigator information and clinical reports as well as co-authored publications in scientific journals as appropriate.
  • Serve as a key member and leader in the TREC division.


Education & Experience
  • PhD, MD, MD/PHD, or equivalent Doctoral degrees.
  • Formal human genetic/genomic training, including fellowship training or board certification preferred.
  • Discovery/basic research experience is preferred.
  • Strong publication record and track history with an international reputation as a superb scientist within field of human genetics.
  • A minimum of 15 years of experience in genetic/genomic research, in positions of increasing responsibility and authority.
Knowledge & Skills
  • Demonstrated, effective, mature leadership is critical, including change management/leadership, strategic talent management, coaching and developing leadership communication, team building, and relationship building,
  • Driving results is essential. Need to be able to motivate others to achieve and exceed goals by establishing accountabilities, clarifying performance expectations, agreeing to high standards and measures, monitoring and reviewing performance, providing timely and relevant feedback and has excellent decision skills.
  • Demonstrated strategic thinker with an ability to create and drive a shared understanding of a long-term vision, particularly in partnership internally and externally.
  • Planning, priority setting, and time management are essential.
  • Accountability takes responsibility for their own performance and accept full ownership of issues, problems, and opportunities, regardless of the source.
  • Strong training, knowledge and experience in Human genetics and genomics.
  • Proven scientific leadership.
  • Ability to see the big picture and provide a long term vision for Takeda. Organizational savvy is important, including ability to gathers and accurately assesses information related to the organization s formal and informal communication channels and power relationships.
  • Enthusiasm for innovative research and ability and desire to lean new approaches and expand core skill set
  • Expertise in regulatory, ICH Guidelines and appropriate regulations
  • Strong project management skills. Ability to appropriately delegate work to accomplish objectives.
  • Team-work, partnership and collaboration skills.
  • Excellent organizational skills.
  • Planning, priority setting and excellent time management are essential.
  • Excellent interpersonal skills; good negotiation and influencing skills
  • Good analytical and problem-solving skills
  • Strong written and verbal communication skills
  • Comfort with ambiguity is required.
  • Eliminates obstacles/barriers in order to implement change. Superior communication, delegation, interpersonal sensitivity, and negotiating skills
  • Diplomacy and positive influencing abilities across multinational business cultures


  • Ph.D, MD or MD/Ph.D., required
The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
  • Ability to sit and stand for long periods of time.
  • Carrying, handling and reaching for objects.
  • Ability to lift and carry over 25 pounds.
  • Manual dexterity to operate office equipment i.e. computers, phones, etc.
  • Access to transportation to attend various meetings held in proximity to the Takeda offices.
  • Willingness to travel to various meetings or sites, including overnight trips. Some international travel may be required. Approximately 20-30% travel is required.


  • 401(k) with company match and Annual Retirement Contribution Plan
  • Tuition reimbursement
  • Company match of charitable contributions
  • Health & Wellness programs including onsite flu shots and health screenings
  • Generous time off for vacation and the option to purchase additional vacation days
  • Community Outreach Programs

we are driven to improve people's lives

Takeda is an EEO employer of minorities, women, disabled, protected veterans, and considers qualified applicants with criminal histories in accordance with applicable laws. For more information, visit

No Phone Calls or Recruiters Please.



Please visit our website at


* If a direct employer requests that you go to their web site and complete your application there in order to be
  considered, please do so. Applications for all positions are subject to each employer's specific requirements.