Posted to MedZilla on 9/23/2017


Takeda Pharmaceuticals

US-CA, Cheminformatician 1700999-MZ


 
 

Are you looking for a patient-focused company that will inspire you and support your career? If so, be empowered to take charge of your future at Takeda. Join us as a Cheminformaticianin our San Diegooffice.

Here, everyone matters and you will be a vital contributor to our inspiring, bold mission. As a Cheminformaticianworking on the Discovery Toxicologyteam, you will be empowered to guide drug discovery projects towards superior drug designand apply data mining and cheminformatic tools, and a typical day will include:

OBJECTIVES:
  • Guide drug discovery projects towards superior drug design and candidate selection through the development of toxicological structure-activity relationships and application of Takeda s early safety screening strategy
  • Apply data mining and cheminformatic tools to collate, interrogate, interpret, and visualize complex, toxicological and ADME-related data
  • Derive mechanistic hypotheses towards resolving toxicological knowledge gaps and drive the development of novel in silico or in vitro technologies to improve the risk assessment process and reduce drug attrition

ACCOUNTABILITIES:

  • Apply Takeda s early safety screening paradigm to early drug discovery projects and identify safety liabilities within chemical series and lead candidates across the Takeda portfolio
  • Provide structure-based risk assessments and influence the direction of drug design into more productive chemical space
  • Create structure-based relational databases to aid in the interrogation, interpretation, and visualization of biological, pharmacokinetic and toxicological data
  • Design, develop and/or validate novel in silico and in vitro solutions that address high-value toxicological knowledge gaps within the safety screening paradigm
  • Work collaboratively on multi-disciplinary projects across multiple therapeutic areas, interacting with toxicology, medicinal chemistry and pharmacology colleagues.

EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS:

  • A demonstrable and strong understanding of medicinal organic chemistry, pharmacokinetics and metabolism is essential
  • A PhD in synthetic organic chemistry is preferred although will consider a related discipline with appropriate drug discovery experience
  • Data mining experience and ability to interrogate, interpret, and visualize biological and toxicological data is essential
  • Experience and ability to work effectively in a matrix, global environment as part of a multidisciplinary team is essential
  • Experience in CNS-related drug discovery projects is desirable
  • Pre-clinical or clinical drug safety experience is desirable
  • Experience with cheminformatic tools is desirable, including for example Pipeline Pilot, Spotfire DXP, the use of scripting languages and the application of machine learning methodologies
  • Awareness of current developments in the ADME sciences and predictive toxicology is desirable
  • Strong, written, oral communication and influencing skills are essential
  • Self-starter with a high level of independence is essential
PHYSICAL DEMANDS:
  • Typical office base
TRAVEL REQUIREMENTS:
  • 10%, both domestic and international

WHAT TAKEDA CAN OFFER YOU:

  • 401(k) with company match and Annual Retirement Contribution Plan
  • Tuition reimbursement
  • Company match of charitable contributions
  • Health & Wellness programs including onsite flu shots and health screenings
  • Generous time off for vacation and the option to purchase additional vacation days
  • Community Outreach Programs

Empowering Our People to Shine

Learn more at takedajobs.com.

Takeda is an EEO employer of minorities, women, disabled, protected veterans, and considers qualified applicants with criminal histories in accordance with applicable laws. For more information, visit http://www.takeda.us/careers/EEO_Policy_Statement.aspx

No Phone Calls or Recruiters Please.

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Schedule

Please visit our website at takedajobs.com

 
 


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