Posted to MedZilla on 6/24/2017

Takeda Pharmaceuticals

US-CA, Staff Scientist, Discovery Biology 1700269-MZ


The Staff Scientist, Discovery Biology will be part of a team focused on early target identification and validation in the therapeutic area of gastrointestinal (GI) diseases. He/she will apply expertise in cell biology and physiology to generate key functional data to test therapeutic hypotheses. This position will work very closely within a matrix team responsible for conducting studies internally as well as in collaboration with external partners. The successful applicant will be an energetic team player, self-directed learner with a keen interest in focused, fast-paced research.


  • Plans and executes experiments characterizing target expression and cellular function in vitro using a wide variety of cell and molecular biology techniques.
  • Designs and conducts ex vivo functional tissue pharmacology experiments.
  • Conducts studies on disease mechanisms and mechanisms of drug action in vitro and in vivo; provides proof of concept for novel therapeutic targets.
  • Manages relationships and projects with contract research organizations conducts ex vivo functional tissue pharmacology experiments.
  • Provides analysis and interpretation of data; write study reports and present data effectively in all settings and with participants of all levels of the organization.
  • Develops and contributes to company s intellectual property domain by ways of patents and/or publications
  • Supports project(s) of defined scope and moderate complexity
  • Represents own research to senior leadership, or for scientific collaborations, or a national scientific conference
  • Works exceptionally well with others in a team that operates as a unit on large projects.
  • Provides assistance and guidance to junior members of the department. Serves as a source of technical expertise within the department.
  • Responsible for maintaining a complete and concise laboratory notebook and writing of experimental procedures for required documents.



  • Ph.D. in a relevant field of biology or equivalent with 0-3 years Post Doc OR MS/MA with at least 10 years related laboratory research experience OR BS/BA with at least 12 years related laboratory research experience
  • Experience and expertise in gastrointestinal research is preferred
  • Ability to plan and execute experiments, critically evaluate and interpret data, and troubleshoot
  • Extensive experience in mammalian cell culture and engineering cell lines
  • Experience in culturing primary cells and assessing cell function by applying a range of in vitro techniques
  • Knowledge and experience with tissue processing and imaging techniques such as confocal microscopy
  • Experience with animal handling, drug administration, knowledge of mouse anatomy and tissue dissection
  • Experience with immunoprecipitation, RT-qPCR, and RNA handling and preparation for microarray preferred
  • Demonstrated ability to multi-task effectively
  • Willingness to work in a team-oriented, dynamic and changing environment
  • Skilled in statistical analysis and graphing programs
  • Excellent written and verbal communication skills


  • Carrying, handling and reaching for objects up to 25 lbs.
  • Carrying, handling and reaching for objects up to 25 lbs.

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