Posted to MedZilla on 3/29/2017


Takeda Pharmaceuticals

US-MA, Discovery Toxicologist- Drug Safety Research Evaluation (DSRE) 1602523-MZ


 
 

OBJECTIVES

  • Provide pharmaceutical drug project teams with expert advice and direction to improve the quality of therapeutics selected for further development based on proactive risk assessment of target- and chemotype-related toxicities
  • Develop comprehensive safety target reviews with risk mitigation plan, apply state of the art in silico and in vitro de-risking strategies to aid in the selection and optimization of large and small molecule therapeutics
  • Lead application, and execution of state of the art in silico and in vitro method development for compound selection and progression

ACCOUNTABILITIES

  • As part of the Global Discovery Toxicology Team work in interdisciplinary teams within and across Global Safety Assessment to provide safety support to early discovery drug hunting teams and engage in core activities within the Discovery Toxicology group
  • Work as part of a team of safety assessment scientists and more broadly DMPK, pathology, pharmacology, and medicinal chemistry experts to implement discovery toxicology strategy to enable the selection and progression of optimized drug candidates
  • Provide target safety review and proactive risk mitigation plan for early drug discovery project teams based on literature, bioinformatic, and other predictive tools
  • Lead the development of early hypothesis-driven investigation into mechanisms of toxicity for the proactive management of potential safety liabilities and communication of impact to teams
  • Apply novel toxicity mechanism-based assays and integrated models to support early target safety and chemistry evaluation.

Qualifications

EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS

  • Minimum of MS with 8 years of pharmaceutical experience or PhD in a scientific discipline with 3 years postdoctoral experience and/or 5+ years of experience working at a pharmaceutical company

LICENSES/CERTIFICATIONS

  • DABT certification desirable
PHYSICAL DEMANDS:
  • Routine demands of an office based environment.
TRAVEL REQUIREMENTS:
  • Ability to travel domestically and internationally, 15%


we are driven to improve people's lives

www.takedajobs.com

Takeda is an EEO employer of minorities, women, disabled, protected veterans. For more information, visithttp://www.takeda.us/careers/EEO_Policy_Statement.aspx

No Phone Calls or Recruiters Please.


*LI-MB2-USA


Schedule
Full-timeQualifications

Please visit our website at takedajobs.com

 
 


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