The Immunology Sr. Scientist colleague develops and performs independent scientific research of moderate scope and complexity with limited supervision. The candidate will serve as a technical leader for TCAL Immunology and help direct research and target discovery efforts.
- Design, develop, and validate relevant in vitro and vivo models for Immunology and GI therapeutic areas.
- Establish cellular models of disease using patient tissue and cells.
- Establish innovative pharmacodynamic and efficacy models.
- Contribute to the development of new translatable disease models, explore disease mechanisms and mechanism of drug action, demonstrating proof of concept for novel therapeutic targets.
- Assume team member representation at project teams. Colleague will actively participate in both departmental and cross-departmental interactions.
- Deliver decisional datasets to facilitate selection of disease settings, discovery and validation of biomarkers.
- Plan, implement and manage internal and external pre-clinical activities and interactions to deliver key experimental studies to support drug candidates in discovery research.
- Identify and apply novel technology and expertise to enhance drug discovery research programs.
- Respond quickly to information learned from ongoing studies and provide input to drug discovery and development management to guide program direction and prioritization.
- Present results both written and verbal and deliver completed reports within a multidisciplinary team environment.
- Key responsibilities include compound formulation, preliminary safety assessment and assessments of efficacy and PK/PD for drug candidates tested alone or in combinations. He/She will closely collaborate/interact with other scientists from Leads Discovery Biology, Medicinal Chemistry, Structural Biology and Analytical Chemistry.
- Diligently performs assigned lab and company responsibilities.
- Maintains concise, accurate, and comprehensible written records as per Takeda California.
EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS:
- PhD or equivalent with 4+ relevant years experience OR MS / MA with 14+ years OR BS / BA with 16+ years
- Has demonstrated independent thought/creativity in science.
- In vivo pharmacology technical proficiency.
- Experience with mucosal immunology preferred.
- Able to present work formally to internal governance bodies
- Able to convey ideas in an experimentally detailed yet scientifically concise manner
- Good communication skills
- Good multitasking skills
- Willing to work flexible hours
- While performing the duties of this job, the colleague is regularly required to use hands to handle animals, palpate tissues/objects, use surgical tools, or controls, and to reach with hands or arms.
- The colleague must lift or move up to 10 pounds on a regular basis in the course of daily activities.
- Ability to drive to or fly to various meetings, or CRO sites including overnight trips.
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