Posted to MedZilla on 3/26/2017

Takeda Pharmaceuticals

US-CA, Associate Scientist, Target Discovery 1602072-MZ



The Associate Scientist, Target Discovery will be part of a team focused

on early target identification and validation in the therapeutic area of

gastrointestinal (GI) diseases. He/she will apply expertise in molecular

biology, biochemistry and in vivo pharmacology to discover novel drug targets,

biomarkers, and biological pathways.


Designs and executes in vitro and in vivo/ex vivo experiments using molecular biology, biochemical, pharmacological or genetic methods to identify and validate novel drug targets with a focus on GI disease area

Characterizes bacTRAP mouse lines using qPCR, immunofluorescence and immunohistochemistry

Designs and executes in vivo studies in relevant disease models, performs ex vivo TRAP experiments including tissue dissection, RNA preparation and amplification, quantitative RT-PCR and RNA-sequencing

Participates in novel drug target identification activities through gene expression profiling, data analysis, public database mining, and literature search

Conducts target validation experiments using a variety of molecular and biochemical methods

Provides analysis and interpretation of data, presents data and project update effectively in department meetings

Proactively manages colonies of transgenic mice and RNAseq activities through CROs

Maintains concise, accurate, and comprehensible written records as per Takeda

Works exceptionally well with others in a fast paced and team environment



MS with 8 or more yrs or B.S. with 10+ yrs. of relevant laboratory experience.

Expertise and extensive experience in molecular and cellular biology, biochemistry, immunohistochemistry and immunofluorescence microscopy.

Hands-on experience in small animal pharmacology and ex vivo assays including dosing, tissue collection, tissue RNA preparation and amplification, tissue gene expression profiling by qPCR.

Knowledge and experience of analyzing RNAseq data and identifying novel drug targets is preferred.

Experience of working with CROs

Ability to work exceptionally well with others in a fast paced, dynamic, and team environment

Excellent communication and organizational skills




Carrying, handling and reaching for objects up to 25 lbs.

Able to work in a lab environment


Willingness and ability to travel occasionally to other research sites

we are driven to improve people's lives

Takeda is an EEO employer of minorities, women, disabled, protected veterans. For more information, visit

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