Posted to MedZilla on 4/25/2017

Takeda Pharmaceuticals

US-MA, Mechanistic Investigative Scientist I/II - Discovery Toxicology 1601930-MZ



  • Help us make safer drugs | Steer pharmaceutical drug project teams with expert advice and direction to design safer, more effective molecules. Improve the quality of therapeutics selected for further development based on proactive risk assessment of target- and chemotype-related toxicities.

  • Deliver decision-making data | Design & deliver of state of the art in vitro and in vivo assays to detect & de-risk toxicities for candidate drug molecules. Provide timely assays and results to drive SAR within a project teams make test cycle.


  • Develop and deliver novel in vitro assays, including traditional cell culture and organ-on-a-chip technologies.
  • Use genomics, molecular & cellular biology to investigate mechanisms of drug-induced toxicity.
  • Steer drug discovery teams to make safer medicines using experience, in-house, and literature data.



  • Growing group needs both masters and PhD-level scientists with 5+ years of industry with knowledge of toxicology.
  • Experience with advanced cell culture approaches with cell lines, primary cells, and iPSC cells.
  • Cell and molecular biology skills including development of reporter assays, application of knock-out, knock-down technology, gene expression analysis, and biomarker assay development and validation.
  • Expertise with Immunotoxicology and hepatotoxicity highly preferred
  • Experience working in a matrixed team environment at a pharmaceutical company and/or CRO.
  • Broad scientific knowledge including pharmacology, toxicology, pathology, physiology and biochemistry.
  • Expertise designing & delivering fit for purpose assays for understanding the mechanism of toxicity of agents including drugs, for biomarker development and application, and for derisking drug candidates.
  • Experience with liver, cardiovascular, gastrointestinal, or immunotoxicity toxicity assays.
  • Skills in pathway analysis, network pharmacology.
  • Strong interpersonal and organizational skills.
  • Excellent oral and written communication skills .

  • DABT certification a plus, but not necessary


  • Routine demands of an office based environment.
  • Ability to travel domestically and internationally, 15%

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Takeda is an EEO employer of minorities, women, disabled, protected veterans. For more information, visit

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