The Integrated Biologics Profiling Unit (IBP) evaluates new therapeutic protein candidates at the transition from research to development identifying candidates with a preferential developability profile. Activities such as cell line development, purification, biophysical profiling, pre-formulation assessment and in vivo fitness are performed by a cross-functional team of motivated scientists from various backgrounds in an international setting. As a pre-formulation expert, you will contribute to the candidate selection and early formulation development activities, supporting a broad variety of molecules in our biologics pipeline.
Lead a team of formulation scientists across two sites and provide scientific and technical leadership, incl. detailed guidance during screen design and data review
Drive IBP s pre-formulation strategy and related initiatives and actively contribute to the overall profiling strategy
Drive project specific profiling and characterization of therapeutic proteins with regard to pre-formulation assessment, e.g. solubility and accelerated stability screens
Act as key contact in cross-functional project teams and as IBP pre-formulation technology expert, ensuring continues improvement of processes with state-of-the-art technologies
Design studies and address specific requirements for new molecule formats and develop appropriate assays considering existing internal know-how as well as information from literature
Interpret physico-chemical characterization of therapeutic proteins using a variety of different HPLC techniques, such as SEC, HIC and various biophysical techniques, e.g. DLS, DSC, DSF, MFI and rheometry
Ensure maintenance of specialized technical equipment and general lab organization
Effectively manage timelines in close collaboration with customers and be able to handle several projects in parallel
The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status.
PhD degree or equivalent in biochemistry, chemistry or related field
A minimum of 4 years of hands-on experience in an industrial setting is required, including design and execution of solubility, forced degradation and stability testing for different molecule formats e.g. antibodies, bispecific Abs, therapeutic proteins or ADCs.
Proficiency in English (oral and written) required
Expert knowledge in high concentration liquid formulations of proteins
Excellent knowledge of biologics characterization (antibodies as well as other formats)
Hands-on experience with a broad spectrum of analytical techniques incl. method development for biologics characterization (e.g. HPLC based separation methods, SVP determination, DLS, rheometry, DSC)
Strong expertise in DOE approaches is required.
Strong ability to quickly grasp new concepts and to address tasks in an independent manner
Ability to lead, influence and coach people. Proven people and resource management skills, with a minimum of 2 years experience in a leadership position e.g. in staff management role, project teams.
Profound inter-personal skills ensuring close collaboration with multiple teams, communication with internal and external partners, and the ability to work in international teams.
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